Postdoctoral Fellow – T-cell Immunology and Viral Diseases Cell-based Medicine

Los Angeles, CA
United States
Life Sciences

An opening for an enthusiastic scientist to work in the Biosciences Division of SRI International is immediately available. Candidates are expected to bring contemporary approaches to engineering primary T cells. Primary responsibilities will include developing adoptive cell therapy using T cells for viral diseases. The successful candidate is expected to develop collaborations with scientific leaders in different areas. The person should be motivated to contribute intellectually in a dynamic team environment.

The Postdoctoral Fellow will genetically engineer primary T cells and validate them in vitro and in vivo for desired efficacy and safety. This will include, but not be limited to, enriching virus-specific primary T cells and quantification of their immune response when stimulated by the target cells. The candidate will develop assays including antigen binding, cell signaling, T cell activation, cytokine release and enzymatic activity. Experience in phage display, antibody engineering and/or vaccine immunology will be a plus.




Education:  PhD in immunology, molecular and cell biology biochemistry, or related field with 0-2 years post-doctoral experience.

The successful candidate is expected to be an independent self-starter with experience and knowledge of contemporary techniques in T-cell immunology (PBMC isolation, transfection techniques, primary T-cell culture, flow cytometry, chromium release assay, cell signaling assay, cytokine release assay, chemotaxis assay, etc.) in the context of viral diseases.  Hands-on expertise in molecular biology of antigen-specific T-cell receptors (TCR), transcriptional regulation, and use of in vivo models in context of viral diseases is desirable.

A post-offer, pre-laboratory placement physical examination may be required. Employment at SRI is contingent on successful completion of a background check.



Apply by submitting CV and cover letter outlining interest and accomplishments via to job number 1458BR.


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