Vedantham lab postdoc
The postdoctoral scholar will work with Dr. Vedantham on molecular cardiovascular research in mouse models related to the mechanisms by which the cardiac conduction system, including pacemaker cells in the sinoatrial node, develop and function. Translational applications of this work will include novel therapeutics to affect heart rate and possibly development of a biological pacemaker. The candidate will focus efforts on projects that include cellular and molecular electrophysiology in isolated cardiomyocytes. There will be abundant opportunity for fruitful collaboration among neighboring investigators.
Dr. Vedantham’s lab is located within the Cardiovascular Research Institute (CVRI) at UCSF, a premier biomedical research facility focused on cardiovascular research. The CVRI has investigators spanning the full range of cardiovascular research including molecular, cellular, animal and patient based. CVRI has an active training program for postdoctoral researchers including opportunities to present research-in-progress and mentoring from senior faculty.
The Division of Cardiology is one of the largest clinical, research and training divisions of the Department of Medicine (DOM) at UCSF. Within the Division are sub-specialty sections for: Adult Congenital Heart Disease; Advanced Heart Failure, Transplant, and Pulmonary Hypertension; Cardiac Electrophysiology; Echocardiography and Cardiac Imaging; General Cardiology, Interventional Cardiology; and Prevention. The Division runs several clinical practices in multiple sites, conducts basic and clinical research, and educates medical students, residents, clinical fellows and postdoctoral scholars through ACGME as well as non-ACGME training programs. In addition, the Division has significant and complex financial and administrative relationships with the Department of Medicine (DOM) and the UCSF Medical Center, as well as large patient care programs in the sections noted above, large clinical, Federal, and privately supported research programs and six faculty laboratories.
The Division has 45 full-time faculty, 4 non-faculty academics, 36 clinical fellows, 3 post-doctoral research fellows, 7 WOS faculty, 2 MSP physicians and 57 research support and administrative staff. The Division currently expends over $22 million per year in pursuit of its clinical, research, training, and service missions. While the Division is primarily split between the Parnassus and Mission Bay campuses, fellows have rotations at the Zuckerberg San Francisco General Hospital and the San Francisco Veterans Affairs Medical Center.
The University of California, San Francisco (UCSF) is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and excellence in patient care. It is the only campus in the 10-campus UC system dedicated exclusively to the health sciences.
- Perform cellular electrophysiology experiments on isolated cardiomyocytes from animal models
- Data analysis of collected data and signal processing.
- Perform standard molecular biological assays (recombinant DNA, cell culture, basic protein work)
- Prepare scholarly manuscripts and submission to journals
- Present research findings at UCSF research/other meetings and national conferences
- PhD or equivalent
- Experience with electrophysiological recording and data analysis using patch clamp techniques
- Experience with basic molecular biology techniques such as PCR, cell culture, Western blot, etc
- Experience working with mice
- Ability to multi-task and work well with limited supervision
- Computer skills with Microsoft, Microsoft Excel, Microsoft PowerPoint, statistical software (such as SPSS)
- Experience in cardiac cellular electrophysiology including primary cardiomyocyte isolation
- Experience with mouse models of heart disease or heart development
- Experience with mouse embryo dissection
- Experience with immunohistochemistry
- Experience with confocal imaging and dynamic calcium imaging using genetically encoded calcium sensors or fluorescent dyes.
- Prior scholarly activity (published abstracts and manuscripts)
Email CV and cover letter directly to Dr. Vedantham at [email protected]